Effect of yoga and naturopathy-based lifestyle modification on left ventricular ejection fraction in a patient with severe triple vessel disease: A case report.

A 75-year-old, married man was diagnosed with coronary artery disease (CAD) [severe triple vessel disease (TVD)] in the 2nd week, June-2018. The physician advised him to undergo conventional medication and coronary artery bypass graft. Since the patient refused to undergo surgery he was admitted in our hospital and underwent yoga and naturopathy-based lifestyle modification (YNLM) along with conventional medicines for 16 weeks [12 weeks of intensive care at inpatient department and 4 weeks at outpatient department (OPD)]. After 16 weeks, the patient visited our OPD once/twice a month for 6 months. An increase in left ventricular ejection fraction from 35 to 48%; and a reduction in weight from 77.5 to 71-kg, and BMI from 26.60 to 24-kg/m2 were observed after 6 months of follow-up compared with baseline. Thus, YNLM might be considered as an adjuvant in reducing risk factor and in improving left ventricular systolic dysfunction in patients with CAD (severe-TVD). However, further studies are required to establish the efficacy of YNLM for CAD.

Lenalidomide-based combined therapy induced alterations in serum proteins of multiple myeloma patient: a follow-up case report and overview of the literature.

AIM: Multiple myeloma (MM) is a malignant neoplasm of plasma cells (PC) derived from the bone marrow (BM) origin. The present case report was aimed to monitor the efficiency of lenalidomide-based combined therapy (LBCT) induced alterations in serum proteins of 42-year-old female MM patient. Besides, in the context of case report we also present an overview of the literature describing LBCT. STUDY DESIGN: Serum protein electrophoresis (SPEP) was performed in three visits (V(1)-V(3)) to monitor the disease status of the patient and her treatment response to LBCT. Level of monoclonal protein (M-protein) was measured through cellulose acetate zone electrophoresis and quantified by densitometer in follow-up investigations after therapy intervals. RESULTS: A significant reduction of M-protein in γ-globulin region was observed (P < 0.007) after receiving LBCT. However, the condition depicted hyper γ-globulinemia. ß-globulin (P < 0.002) and α(2)-globulin(P < 0.047) was suppressed from the initial visit and subsequent follow-up also indicated the status of hypoglobulinaemia. Although, serum albumin level was found to be increased after therapy (P < 0.016), hypoalbuminaemia was also noticed before and after LBCT. CONCLUSION: On the basis of this case report and pertinent literature, we conclude that LBCT is more efficient in the treatment of MM and has significant role in serum protein alterations especially in the reduction of M-protein in the MM patients.